Clinical Research
Doctoral programme (PhD)
A.Y. 2019/2020
Study area
Medicine and Healthcare
PhD Coordinator
Students will learn a correct research approach for studying the causes and the clinical-therapeutic management of diseases.
Specific objectives:
identify clinical issues and uncertainties in pathogenesis, diagnosis, prognosis and in therapeutic approaches in various diseases;
correctly apply different research methodologies (randomized trials, longitudinal, cross-sectional or transversal studies and case control studies);
identify and use biological and genetic markers for studying clinical syndromes, guiding diagnosis and assessing the clinical outcome of different pathologies;
develop critical skills to analyse and comment clinical research results published or presented at national and international conferences;
introduce students to independent clinical research methods and to the issues and critical points relating to ethics in clinical research.
The programme is entirely in English.
Specific objectives:
identify clinical issues and uncertainties in pathogenesis, diagnosis, prognosis and in therapeutic approaches in various diseases;
correctly apply different research methodologies (randomized trials, longitudinal, cross-sectional or transversal studies and case control studies);
identify and use biological and genetic markers for studying clinical syndromes, guiding diagnosis and assessing the clinical outcome of different pathologies;
develop critical skills to analyse and comment clinical research results published or presented at national and international conferences;
introduce students to independent clinical research methods and to the issues and critical points relating to ethics in clinical research.
The programme is entirely in English.
Possono presentare domanda di partecipazione al concorso di ammissione al dottorato di ricerca coloro i quali siano in possesso di laurea magistrale LM-41 - Medicina e chirurgia, che, nell'anno accademico 2019/2020, inizieranno il loro ultimo anno di una scuola di specializzazione di area medica dell'Università degli Studi di Milano e laureati magistrali nella LM-41 - Medicina e chirurgia, e in possesso del diploma di specializzazione di area medica.
Possono inoltre presentare domanda di partecipazione i possessori di laurea magistrale in Odontoiatria e protesi dentaria (LM-46).
Possono inoltre presentare domanda di partecipazione i possessori di laurea magistrale in Odontoiatria e protesi dentaria (LM-46).
Dipartimento di Fisiopatologia medico-chirurgica e dei trapianti, Via F. Sforza, 35 - 20122 Milano
- Main offices
Dipartimento di Fisiopatologia medico-chirurgica e dei trapianti, Via F. Sforza, 35 - 20122 Milano - Degree course coordinator: Emilio Berti
emilio.berti@unimi.it - Degree course website
http://www.dept.unimi.it/ecm/home/didattica/dottorati
| Title | Professor(s) |
|---|---|
| 1. Rare autoimmune diseases. 2. Rare skin tumours.
Curriculum: Scienze mediche specialistiche |
|
| 1. Epidemiology, diagnostic pathways and therapy of protozoan diseases (malaria, leishmaniasis, Chagas disease). 2. Antimicrobial stewardship routes.
Curriculum: Scienze mediche specialistiche |
|
| Epidemiology, pathophysiology, clinics, therapy and complications of the hypotalamic-hypophysis diseases.
Curriculum: Scienze mediche specialistiche |
|
| Morphological and functional adaptation of right ventricle ad different stages of pulmonary circulation involvement in heart failure patients with reduced ejection fraction.
Curriculum: Scienze mediche specialistiche |
|
| 1. Evaluation of new biomarkers of cardiovascular risk in subjects with non-alcoholic fatty liver disease (NAFLD) or diabetes mellitus identified in the general population. 2. Platelet function and cardiovascular risk.
Curriculum: Scienze mediche specialistiche |
|
| 1. Diseases of the pericardium. 2. Pregnancy in autoimmune diseases.
Curriculum: Scienze mediche specialistiche |
|
| Neurodevelopmental disorders and epilepsy.
Curriculum: Scienze mediche specialistiche |
|
| Image-guided percutaneous thermal ablation in the treatment of malignant and benign tumors.
Curriculum: Scienze mediche specialistiche |
|
| Use of respiratory function tests for the diagnosis and follow-up of complex respiratory diseases.
Curriculum: Scienze mediche specialistiche |
|
| Endocrine disorders in patients with common diseases (diabetes mellitus and/or obesity and/or hypertension).
Requisiti: Knowledge of endocrinology and metabolism, basic-level skills in next-generation sequencing techniques and statistics applied to biomedical research. Curriculum: Scienze mediche specialistiche |
|
| 1. Clinical methodology (critical evaluation of choosing in medicine and scientific literature). 2. Risk stratification in cardiovascular diseases and in emergency situations, expecially in syncope.
Curriculum: Scienze mediche specialistiche |
|
| Study of microcirculation:pathophysiologic and clinical implications.
Curriculum: Scienze mediche specialistiche |
|
| 1. Immunopathogenesis of viral infections. 2. Role of the microbiome in MDR bacteria colonization. 3. Antimicrobial stewardship in medicine departments: role in the control of nosocomial infections.
Curriculum: Scienze mediche specialistiche |
|
| Modulation of the metabolism of the malignancies through the use of metformina and fast mimicking diet.
Curriculum: Scienze mediche specialistiche |
|
| 1. Physiopathological mechanisms of insulin-resistance in obesity and diabetes. 2. Implications for atherosclerosis acceleration and microvascular complications.
Curriculum: Scienze mediche specialistiche |
|
| Metabolic and cardiovascular complications in non- alcoholic fatty liver disease (NAFLD) from adolescence to adults.
Curriculum: Scienze mediche specialistiche |
|
| The infection associated cryoglobulinemie: pathogenesis, genetic relates and therapy.
Curriculum: Scienze mediche specialistiche |
|
| Retinal and choroidal disorders.
Curriculum: Scienze mediche specialistiche |
|
| Immunotherapy in head and neck tumours.
Curriculum: Scienze mediche specialistiche |
|
| 1. Development of personalized therapies in tumors of the nervous system. 2. New knowledge and surgical therapies in movement disorders.
Curriculum: Scienze mediche specialistiche |
|
| Use of transcranic electromagnetic stimulation for the treatment of the endocrino-metabolic diseases.
Curriculum: Scienze mediche specialistiche |
|
| 1. Urothelial cancer: new diagnostic and therapeutic approaches. 2. Translational analysis of the impact of HLA-G-related tolerance in overall health in infertile vs. fertile men.
Curriculum: Scienze mediche specialistiche |
|
| Assesment and modulation of autonomic nervous system in acute and chronic diseases.
Curriculum: Scienze mediche specialistiche |
|
| Multiparametric, vascular, structural and functional study with RMN in Parkinson's disease.
Curriculum: Scienze mediche specialistiche |
R. Nemni
|
| 1. Pathophysiology, clinics and personalized therapeutic strategies in myelodisplastic syndrom and myelodisplastic/myeloproliferative disorders. 2. Allogeneic transplantation of hemopoietic stem-cells and cell therapy in onco-hematology.
Curriculum: Scienze mediche specialistiche |
|
| 1. Pathophysiology, diagnosis and therapy of esophageal diseases. 2. Endoscopic treatment of biliar diseases, especially of the biliar complications after liver transplantation.
Curriculum: Scienze mediche specialistiche |
|
| HIV infection: clinical, metabolic and pharmacological correlates and focus on genotypic and phenotypic resistance.
Curriculum: Scienze mediche specialistiche |
|
| Setup of a national database for the functional, respiratoty and clinical characterization in a wide population of patients suffering from cronic obstructive broncho-pulmonary disease.
Curriculum: Scienze mediche specialistiche |
|
| Impact of hypophysis disease on morbility, wellness, physical and working performance.
Curriculum: Scienze mediche specialistiche |
|
| Evaluation of the cardiovascular autonomic control in patients suffering from systemic sclerosis.
Curriculum: Scienze mediche specialistiche |
|
| New pathophysiological knowledge for the design of endovascular treatment of thoracic and abdominal aorta diseases.
Curriculum: Scienze mediche specialistiche |
|
| 1. Safety and efficacy of the Thulium laser system for endoscopic therapy of gastrointestinal lesions: a multicenter study. 2. Novel biomarkers for complicated and non-responsive celiac disease.
Curriculum: Scienze mediche specialistiche |
|
| 1. Epileptic encephalopathies: clinics and traditional and innovative therapeutic approach. 2. Glucose transporter type 1 deficiency syndrome (Glut 1 disease): physiopathology, clinics and therapy.
Curriculum: Scienze mediche specialistiche |
|
| 1. Analysis of the functional outcome in the treatment of inferior alveolar nerve lesions with autologous nerve graft (sural nerve), processed heterologous nerve graft (cryopreserved), and alloplastic graft (collagen tubule). 2. Use of ultrasonic method in the intraoperative evaluation of surgical resection margins of extracranic artero-venous malformations of the cranial-facial region.
Curriculum: Scienze odontostomatologiche |
|
| Radioprotection in medicine concerning diagnosis treatment and therapy. Risks and benefits evaluation regarding patient characteristics.
Curriculum: Scienze odontostomatologiche |
|
| 1. Development and clinical application of new collagen xenogenous matrices for the regeneration of intra-oral soft tissues. 2. Development and clinical applications of customized Cad/cam titanium meshes for guided bone regeneration of atrophic edentulous jaws.
Curriculum: Scienze odontostomatologiche |
|
| Autologous dentin matrix and platelet concentrates for alveolar site preservation and bone defects reconstruction procedures in oral surgery.
Curriculum: Scienze odontostomatologiche |
|
| Morphofunctional analyses of organs and tissues of the oral system.
Curriculum: Scienze odontostomatologiche |
|
| Development of diagnostic, prognostic and therapeutic programmes using three-dimensional digital and radiographic images in dentistry.
Curriculum: Scienze odontostomatologiche |
|
| 1. Nasal Function. 2. Sleep disorders in ENT.
Curriculum: Scienze odontostomatologiche |
|
| Modern therapeutic approaches for periodontal and peri-implant diseases.
Curriculum: Scienze odontostomatologiche |
|
| Biological and imaging markers for differential diagnosis and prognosis of neurodegenerative and demyelinating diseases of the central nervous system.
Curriculum: Scienze odontostomatologiche |
|
| Custom-made maxillary and mandibular reconstructions prior to implant surgery and maxillofacial oncologic surgery.
Curriculum: Scienze odontostomatologiche |
|
| Role of the autologous adipose tissue in tissue regeneration, in fibrosis reduction and in scar-pain control.
Curriculum: Scienze odontostomatologiche |
|
| Etiopathogenesis, diagnosis, treatment and prognosis of mucosal lesions with particular attention towards potentially malignant ones.
Curriculum: Scienze odontostomatologiche |
|
| Use of titanium grids for the pre-implant bone regeneration.
Curriculum: Scienze odontostomatologiche |
|
| 1. Recurrent infective-inflammatory disease of the upper airways. 2. Mini-invasive surgery for airways obstructions.
Curriculum: Scienze odontostomatologiche |
|
| Single edentulism treatment through implant-supported rehabilitation with autologous connective or heterologous matrix graft. Multicentric, randomized controlled study.
Curriculum: Scienze odontostomatologiche |
|
| 1. Effects of biophysical stimolation on musculo-skeletal tissues. Experimental study on the osteo-reparative response in the Zebra Fish. 2. Evaluation of transendothelial migration of monocytes in joints of obese patients with osteoarthrosis: prospective randomized clinical study.
Curriculum: Scienze odontostomatologiche |
|
| Diagnostic, interventional and quantitative radiology of the musculoskeletal system.
Curriculum: Scienze odontostomatologiche |
|
| Evaluation of molecules with anti-biofilm activity for the prevention and treatment of peri-implantitis.
Curriculum: Scienze odontostomatologiche |
|
| Efficacy of laser biostimulation in pain and oedema reduction after impacted mandibular third molar extraction: multicentric, randomized study.
Curriculum: Scienze odontostomatologiche |
|
| 1. Study and treatment of the pathologies of cornea and ocular surface. 2. The eye: a window to the soul of the immune system.
Curriculum: Scienze odontostomatologiche |
|
| Study of the progression of reticular drusen.
Curriculum: Scienze odontostomatologiche |
|
| The complications in clinical trial: management and medical liability.
Curriculum: Scienze odontostomatologiche |
|
| 1. Regeneration of Periodontal and peri-implant tissues, in particular surgical techniques, scaffolds and growth factors. 2. Development of 3D printed scaffolds for the regeneration of maxillary processes.
Curriculum: Scienze odontostomatologiche |
Courses list
January
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Histological diagnosis of cutaneous melanocytic lesions | 10 | 50 | Italian | |
| Updates in Cranio-Maxillofacial Sciences | 4 | 24 | English | |
February
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Oral Microbiology | 3 | 16 | English | |
| Pandora EVOLUTION in Infectious Diseases Management | 5 | 28 | Italian | |
| Pregnancy in rheumatic diseases | 4 | 20 | Italian | |
March
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Endocrine disorders in patients with common diseases (diabetes mellitus and/or obesity and/or hypertension) | 5 | 25 | Italian | |
| High-level course on pericardial diseases | 4 | 20 | Italian | |
| Systematic Reviews and Meta-analyses | 2 | 12 | English | |
May
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Biomaterials and Regeneration Techniques in Clinical Applications | 5 | 28 | English | |
November
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Cutaneous Lymphomas | 10 | 66 | Italian | |
| Statistics and Research Methodology in Clinical Research | 4 | 24 | English | |
| Updates in clinical and experimental Endocrinology | 8 | 40 | Italian | |
January
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Histological diagnosis of cutaneous melanocytic lesions | 10 | 50 | Italian | |
| Updates in Cranio-Maxillofacial Sciences | 4 | 24 | English | |
February
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Oral Microbiology | 3 | 16 | English | |
| Pregnancy in rheumatic diseases | 4 | 20 | Italian | |
March
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Endocrine disorders in patients with common diseases (diabetes mellitus and/or obesity and/or hypertension) | 5 | 25 | Italian | |
| High-level course on pericardial diseases | 4 | 20 | Italian | |
| Systematic Reviews and Meta-analyses | 2 | 12 | English | |
May
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Biomaterials and Regeneration Techniques in Clinical Applications | 5 | 28 | English | |
November
| Courses or activities | Professor(s) | ECTS | Total hours | Language |
|---|---|---|---|---|
| Optional | ||||
| Cutaneous Lymphomas | 10 | 66 | Italian | |
| Statistics and Research Methodology in Clinical Research | 4 | 24 | English | |
| Updates in clinical and experimental Endocrinology | 8 | 40 | Italian | |
Following the programme of study
Contacts
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